This Week in Virology (TWiV) #112: Creating a killer poxvirus

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes.

Download TWiV #112 ( MB .mp3, minutes). To download, right-click or control-click on the link, then select save as.

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Links for this episode:

• Expression of IL-4 makes a killer poxvirus
• Additional studies on poxvirus-IL-4 recombinants
• Creation of killer poxvirus could have been predicted
• Interleukin regulation of Th responses
• Severe pandemic H1N1 disease due to immune complexes
• Unusually high influenza mortality in 18-65 years old
• The complement system
• TWiV on Facebook
• Letters read on TWiV 112

Weekly Science Picks

Rich - The Scientist's Top 10 Innovations 2010
Alan - Avian Vocalizations Center
Vincent - Microbial soap from Cleaner Science (thanks, Nadia!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.